Guan Shu Hui's (Paige Chua) domineering ways causes a rift between her husband Qi Hong Zhe (Thomas Ong) and his family. Hong Zhe is unhappy with his wife but chooses to put up with her, until Zhou Ke En (Chris Tong) enters his life. Ke En is pretty, intelligent and most of all, she listens to Hong Zhe's problem and supports his dreams. Ke En also manages to win the approval of Hong Zhe's family, leaving Shu Hui feeling helpless. Shu Hui's estranged mother Lu Xiu Zhu (Li Ping Chen) steps in and tries to salvage her daughter's marriage. Xiu Zhu tries to outwit Ke En who is actually a malicious and mentally unstable woman. How will the battle between the mightiest mistress and the mightiest Mother-in-Law end? Will Shu Hui be able to save her marriage?
